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Show oumai or Neuro- Ophthahiiology The Official Journal of the North American Neuro- Ophthalmology Society December 2002 • Volume 22 • Number 4 EDITORIAL 257 From Genotype to Phenotype in Leber Hereditary Optic Neuropathy: Still More Questions than Answers Nancy J. Newman STATE OF THE ART 279 The Eyes of Mito- Mouse: Mouse Models of Mitochondrial Disease Valerie Biousse, Machelle T. Pardue, Douglas C. Wallace, and Nancy J. Newman ORIGINAL CONTRIBUTIONS 262 Lightning Strikes Twice: Leber Hereditary Optic Neuropathy Families with Two Pathogenic mtDNA Mutations Neil Howell, Neil R. Miller, David A. Mackey, Anthony Arnold, Corinna Herrnstadt, Ma M. Williams, and Iwona Kubacka 270 Contrast Letter Acuity as a Measure of Visual Dysfunction in Patients with Friedreich Ataxia David R. Lynch, Jennifer M. Farmer, Dustin Rochestie, and Laura J. Balcer 275 Nerve Sheath Tumors of the Sellar Region Sumedha Bhagat, Colin Smith, Graham M. Teasdale, and Robert M. McFadzean NANOS SYMPOSIUM 2002 286 Developmental Neurogenetics and Neuro- Ophthalmology Jeffrey L. Bennett 297 Practical Approaches to Neurogenetic Disease David R. Lynch and Jennifer Farmer NEURO- OPHTHALMOLOGY AT LARGE 305 14th International Neuro- Ophthalmology Society ( INOS) Meeting, Buenos Aires, Argentina, May 5- 8, 2002 Robert M. McFadzean and Luis J. Mejico ( continued on next page) Listed in Index Medicus/ MEDLINE, Current Contents/ Clinical Medicine, SCISEARCH, Biomedical Database, Ocular Resources Review, and in Automatic Subject Citation Alert; listed and abstracted in Ophthalmic Literature and in Stroke. Journal of Neuro- Ophthalmology ( ISSN: # 1070- 8022), is published quarterly in March, June, September, and December by Lippincott Williams & Wilkins, at 16522 Hunters Green Parkway, Hagerstown, MD 21740- 2116. Business and production offices are located at 530 Walnut Street, Philadelphia, PA 19106- 3621. 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Unauthorized reproduction of this article is prohibited. Contents ( continued) NANOSNEWS 315 ACKNOWLEDGMENT OF REVIEWERS 311 Carol Francis Zimmerman, MD, February 27, 1952- March27,2001 317 AUTHOR INDEX R. NickHogan 313 CALENDAR 319 SUBJECT INDEX Lippincott Williams & Wilkins, Inc., cannot be held responsible for errors or for any consequences arising from the use of the information contained in this journal. The appearance of advertising in this journal does not constitute an endorsement or approval by Lippincott Williams & Wilkins, Inc., of the quality or value of the product advertised or of the claims made for it by its manufacturer. PERMISSION TO PHOTOCOPY ARTICLES: This publication is protected by copyright. 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