Arthritis, Rheumatoiddrug therapy Corticotropintherapeutic use Adrenal Cortexmetabolism
Cyprus Medical Journal, v. 4, n. 4, 1951[pg.583-593]
Since the original report by Hench and his collaborators in 1949 on the dramatic effects of cortisone and ACTH (adrenocorticotrophic hormone) in patients suffering from rheumatoid arthritis, a large amount of work has been done on the effect of these substances in this and other diseases, and many have been found to react with favorable clinical responses. Whereas the rheumatoid process is affected directly by cortisone, by some means, as yet poorly understood, the effect of ACTH is an indirect one by virtue of its property of stimulating the adrenal cortex of the recipient to secrete steroid compounds akin to cortisone, and this fact cannot be over-emphasized. Since the whole range of activity controlled by the adrenal cortex appears to be stimulated by ACTH, the effect on the recipient of the secreted steroids tends to be more complex than the effect produced by the administration of cortisone.