| Publication Type |
thesis |
| School or College |
School of Medicine |
| Department |
Pathology |
| Author |
Meola, Stacy D. |
| Title |
Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model |
| Date |
2001-08 |
| Description |
Anticoagulant and antiplatelet agents are currently being used clinically during episodes of unstable angina and non-Q-wave myocardial infarctions to stop thrombus formation to decrease morbidly and mortality. In vitro and ex vivo stent models were developed to assess thrombus formation, platelet incorporation and emboli development utilizing combinations of anticoagulant (heparin) and antiplatelet (Aggrastat ®) agents. The ex vivo model assessed thrombus and emboli formation in an ovine shunt model for nine drug combinations using gravimetric analysis and an unique light scattering microemboli detector (LSMS) to assess emboli in flowing blood. The in vitro model compared five therapy relationships using a one-pass bovine blood model using gravimetric analysis, radio-labeled platelets, and the LSMD. The results confirm that a combination therapy utilizing an anticoagulant and antiplatelet drug therapy the total thrombus weight and emboli produced can be decreased as compared to using an anticoagulant alone. |
| Type |
Text |
| Publisher |
University of Utah |
| Subject |
Heparin; Thrombus |
| Subject MESH |
Anticoagulants; Drug Therapy; Splints |
| Dissertation Institution |
University of Utah |
| Dissertation Name |
MS |
| Language |
eng |
| Relation is Version of |
Digital reproduction of "Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model." Spencer S. Eccles Health Sciences Library. Print version of "Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model." available at J. Willard Marriott Library Special Collection. RC39.5 2001 .M46. |
| Rights Management |
© Stacy D. Meola. |
| Format Medium |
application/pdf |
| Format Extent |
2,099,496 bytes |
| Identifier |
undthes,5235 |
| Source |
Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available). |
| Master File Extent |
2,099,534 bytes |
| ARK |
ark:/87278/s61z469h |
| Setname |
ir_etd |
| ID |
191814 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s61z469h |
