Selection of a biochemical marker for the early detection of acute myocardial infarction

Update Item Information
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Chynan, Yii-Wuu Simon
Title Selection of a biochemical marker for the early detection of acute myocardial infarction
Date 1991-12
Description Optimum use of thrombolytic therapy for patients with acute myocardial infarction (MI) requires an early diagnosis so that agents can be administered as early as possible after the onset of chest pain. Serum myoglobin and creatine kinase-MM (CK-MM) isoforms have been found to be sensitive and early markers for MI compared to CK-MB isoenzyme. Serum myoglobin, CK-MM isoforms and CK-MB activity were measured by radioimmunoassay, isoelectrofocusing and agarose gel electrophoresis, respectively, in serial serum specimens from patients diagnosed with acute MI, burn and trauma. Total CK and total lactate dehydrogenase were also monitored and were analyzed by an autoanalyzer procedure. Both the MM3/MM1 ratio and the myoglobin level were elevated even in the first sample in 16 of 20 MI patients and within 1.2 hr in most of the other cases; CK-MB was elevated in the first sample only in 50% of the cases and took four to 6.5 hr in some cases to show above normal levels. Also, the MM3/MM1 ratio and serum myoglobin reached peak levels four to six hr earlier than CK-MB. There was no significant difference (p>0.1) between the time of appearance of elevated MM3/MM1 ratio and myoglobin level. The duration and the magnitude of elevation of these markers, however, were different from each other, with myoglobin remaining elevated significantly longer than MM3/MM1 ratio. Thirteen of 18 burn patients and 7 of 12 trauma patients had above-normal MM3/MM1 ratio and myoglobin level; therefore, evidently CK-MM isoforms and myoglobin are nonspecific in burn and trauma patients. Because of the availability of rapid methods of testing for serum myoglobin and its longer duration of elevation, serum myoglobin is recommended as the test of choice for early detection of MI.
Type Text
Publisher University of Utah
Subject Diagnosis; Myoglobin; Lactate Dehydrogenase:
Subject MESH Biological Markers; Creatine Kinase; Laboratory Techniques and Procedures; Myocardial Infarction; Serologic Tests; Myoglobin
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Selection of a biochemical marker for the early detection of acute myocardial infarction". Spencer S. Eccles Health Sciences Library. Print version of "Selection of a biochemical marker for the early detection of acute myocardial infarction". available at J. Willard Marriott Library Special Collection. RC39.5 1991 .C49.
Rights Management © Yii-Wuu Simon Chynan.
Format Medium application/pdf
Format Extent 880,958 bytes
Identifier undthes,4442
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Republic of China Navy.
Master File Extent 881,083 bytes
ARK ark:/87278/s6fj2jh5
Setname ir_etd
ID 190556
Reference URL https://collections.lib.utah.edu/ark:/87278/s6fj2jh5