Comparative effects of immunoglobulins and immunoglobulin fragments on the immune response of rabbits

Update Item Information
Publication Type thesis
School or College School of Medicine
Department Biomedical Informatics
Author Beard, Michael Arthur
Title Comparative effects of immunoglobulins and immunoglobulin fragments on the immune response of rabbits
Date 1970-08
Description Immunosuppression by passive transfer of antibody has been extensively studied and has resulted in at least one practical human application. Human immunoglobulin G anti-Rho is now used widely in the prevention of Rh antibody production by Rh negative mothers. Although considerable knowledge has accrued concerning the mechanisms involved, many aspects of the role of passive antibody are still uncertain. The principal purpose of this was to determine if the low molecular weight subunit ( ? 160,000) of the IgM molecule is similar to the entire molecule (? 160,000 MW) of IgG and IgM (1,000,000) in regards to its capacity to cause immunosuppression. Rabbits immunized with human erythrocytes and injected with homologous immunoglobulins or their fractions were found to vary quantitatively in their ability to produce antibody. Homologous anti-human erythrocyte IgG exhibited the greatest capability to cause immunosuppression. Homologous, specific IgM appeared much less capable in suppression of antibody production. Homologous IgM low molecular weight fragments had little or no effect on antibody production.
Type Text
Publisher University of Utah
Subject Antibody; Physiochemical
Subject MESH Immunoglobulins; Rabbits
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Comparative effects of immunoglobulins and immunoglobulin fragments on the immune response of rabbits." Spencer S. Eccles Health Sciences Library. Print version of "Comparative effects of immunoglobulins and immunoglobulin fragments on the immune response of rabbits." available at J. Willard Marriott Library Special Collection. QR6.5 1970 .B4.
Rights Management © Michael Arthur Beard.
Format Medium application/pdf
Format Extent 1,145,854 bytes
Identifier undthes,5067
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Public Health Service, Allied Health Professions Advanced Traineeship Grant.
Master File Extent 1,145,879 bytes
ARK ark:/87278/s6bg2qrr
Setname ir_etd
ID 190611
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bg2qrr