| Publication Type |
thesis |
| School or College |
School of Medicine |
| Department |
Biomedical Informatics |
| Author |
Xu, Zhenzhe |
| Title |
Simulation study for noninvasive measurement of mean systemic transit time |
| Date |
1989-12 |
| Description |
The total body blood volume can be calculated by the product of mean systemic transit time (t) and cardiac output. This study has developed the mathematical procedures that, based on feedback analysis of linear time invariant systems for extracting mean systemic transit time from [18]O[2] and inert gas profiles, determined the accuracy of the mean systemic transit time calculating algorithms under simulated conditions which model pulmonary states from normal to severely abnormal. These states are used to test the hypothesis that the mean [18]O[2] systemic transit time can be determined to within 15% with model simulating patients have lungs with ventilation-perfusion ratio distributions in nonuniformity from normal to severely nonuniform [as in patients with severe chronic obstructive pulmonary disease (COPD)]. Literature ventilation-perfusion ration distribution data for normal, restrictive lung disease (RLD), and COPD subjects (from Wagner) have been used in the simulation study. The reliability of this measurement has been tested when different types of random noise have been added into the measured signals. |
| Type |
Text |
| Publisher |
University of Utah |
| Subject |
Mathematical Computing; Medical Informatics Computing; Models, Theoretical; Monitoring, Physiologic; Pulmonary Circulation; Signal Processing, Computer-Assisted |
| Subject MESH |
Blood Volume Determination; Cardiac Output; Computer Simulation; Indicator Dilution Techniques; Lung Diseases, Obstructive |
| Dissertation Institution |
University of Utah |
| Dissertation Name |
MS |
| Language |
eng |
| Relation is Version of |
Digital reproduction of "Simulation study for noninvasive measurement of mean systemic transit time." Spencer S. Eccles Health Sciences Library. Print version of "Simulation study for noninvasive measurement of mean systemic transit time." available at J. Willard Marriott Library Special Collection. QP6.5 1989 .X8. |
| Rights Management |
© Zhenzhe Xu. |
| Format Medium |
application/pdf |
| Format Extent |
758,662 bytes |
| Identifier |
undthes,5239 |
| Source |
Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available). |
| Master File Extent |
758,785 bytes |
| ARK |
ark:/87278/s6377bgx |
| Setname |
ir_etd |
| ID |
190760 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6377bgx |
