New numerical method for noninvasive cardiac output measurement

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Publication Type thesis
School or College School of Medicine
Department Biomedical Informatics
Author Duncan, Jeffrey D.
Title New numerical method for noninvasive cardiac output measurement
Date 1995-12
Description The Synchronous Tracer Injection method (STI), based on inert gas techniques for determining the distribution of ventilation with respect to the ratio of ventilation to perfusion in the lung, relies upon mathematical models to describe gas exchange relationships in the lung. Solution of these models requires optimization of systems of nonlinear equations, a task that is complicated by the sensitivity to noise and the lack of global convergence of conventional optimization algorithms, The Fast Randomized Input (FRI) method, loosely based on multistart global optimization techniques, was developed to provide global solutions to the STI model equations in the presence of noisy data. The FRI method was tested on a variety of V/Q distributions representing normal and diseased lungs at levels of noise as high as 4%. In addition, the effect of increased F-i-O-2 on the STI calculation of effective shunt was tested. Additionally, the effect of model complexity on the uncertainty of solutions is addressed, and considerations for choice of model complexity are discussed.
Type Text
Publisher University of Utah
Subject Tracer Injection Method
Subject MESH Cardiac Output; Heart Function Tests
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "New numerical method for noninvasive cardiac output measureme". Spencer S. Eccles Health Sciences Library. Print version of "New numerical method for noninvasive cardiac output measureme" available at J. Willard Marriott Library Special Collection. RC39.5 1995 .D85.
Rights Management © Jeffrey D. Duncan.
Format Medium application/pdf
Format Extent 1,028,218 bytes
Identifier undthes,4122
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Master File Extent 1,028,255 bytes
ARK ark:/87278/s6f191jw
Setname ir_etd
ID 191246
Reference URL https://collections.lib.utah.edu/ark:/87278/s6f191jw