Evidence for activation of cyclic AMP in a bulbospinal noradrenergic pathway.

Update Item Information
Publication Type thesis
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Peterson, Robert Gordon.
Title Evidence for activation of cyclic AMP in a bulbospinal noradrenergic pathway.
Date 1979-06
Description Previous studies indicate that sympathetic preganglionic neurons (SPGNs) receive reciprocal innervation by two bulbospinal monoaminergic pathways, norepinephrine (NE) pathways being excitatory and 5-hydroxy-tryptamine (5-HT) pathways being inhibitory. Two phosphodiesterase inhibitors were tested to evaluate whether cyclic AMP is generated in SPGNs following excitation by NE pathways. Sympathetic discharges recorded from preganglionic rami were evoked in spinal cats by stimulating descending excitatory pathways in the cervical spinal cord or by stimulating thoracic spinal reflex pathways. Aminophylline and isobutyl-methyl-xanthine rapidly and markedly enhanced transmission through the intraspinal pathway. Enhancement was not significantly altered by depletion of 5-HT. Aminophylline also enhanced transmission through the spinal reflex pathway, but the onset of enhancement and the time to maximal enhancement were significantly delayed. The results support the proposal that cyclic AMP is generated in SPGNs in response to NE. Activation of cyclic AMP by spinal reflex pathways appears to be mediated by a different mechanism.
Type Text
Publisher University of Utah
Subject Neurophysiology; Aminophylline
Subject MESH Cyclic AMP-Dependent Protein Kinases; Neurons
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Evidence for activation of cyclic AMP in a bulbospinal noradrenergic pathway." Spencer S. Eccles Health Sciences Library. Print version of "Evidence for activation of cyclic AMP in a bulbospinal noradrenergic pathway." available at J. Willard Marriott Library Special Collection. RM 31.5 1979 P48
Rights Management © Robert Gordon Peterson II.
Format Medium application/pdf
Identifier us-etd2,23
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Montana Heart Association and by NIH Grant Gm-07579.
ARK ark:/87278/s66d67k9
Setname ir_etd
ID 193282
Reference URL https://collections.lib.utah.edu/ark:/87278/s66d67k9