Factors responsible for the differential survival of heart and skin allografts in inbred rats.

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Publication Type dissertation
School or College School of Medicine
Department Pathology
Author Warren, Reed Parley
Title Factors responsible for the differential survival of heart and skin allografts in inbred rats.
Date 1973-06
Description It is common observation that orthotopic skin allografts are rejected acutely across certain histoincompatibility barriers in which surgically anastomosed hearts often survive for many months. In three normal or treated rat strain combinations that exhibit this pattern, neonatal heart tissue grafted in a free manner analogous to skin grafting (requiring natural vascularization, ischemic stress etc.) was also found to be rejected acutely. Consequently the differential survival of surgically anastomosed heart and skin allografts seems due to differences in the mode of grafting these tissues and not to different tissue specific antigens or inherent differential vulnerability of skin and heart. In addition the survival of these freely grafted heart as well as skin allografts were greatly extended when they were transplanted with surgically anastomosed hearts of the same inbred strain. This extension of survival appeared to result from the ability of surgically anastomosed hearts to induce unresponsiveness in their recipients. Subsequent experiments characterized this unresponsiveness as being immunological enhancement. Sera from heart organ allograft recipients passively enhanced the survival of freely grafted heart allografts. In addition, by the leucocyte migration test, lymph node cells and sera, respectively, from some of the heart recipients produced migration inhibition factor when exposed to antigen in culture and blocked production of the same.
Type Text
Publisher University of Utah
Subject Immunology; Rats
Subject MESH Graft vs Host Disease; Heart Transplantation; Skin Transplantation
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Factors responsible for the differential survival of heart and skin allografts in inbred rats." Spencer S. Eccles Health Sciences Library. Print version of "Factors responsible for the differential survival of heart and skin allografts in inbred rats." available at J. Willard Marriott Library Special Collection. QP6.5 1973 .W3.
Rights Management © Reed Parley Warren.
Format Medium application/pdf
Identifier us-etd2,18996
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6zw21jh
Setname ir_etd
ID 193662
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zw21jh