| Publication Type |
dissertation |
| School or College |
College of Pharmacy |
| Department |
Medicinal Chemistry |
| Author |
Cang, Xiaohui |
| Title |
Molecular dynamics simulations on G-quadruplexes |
| Date |
2010-12 |
| Description |
Guanine-rich DNA/RNA sequences have the potential to form four-stranded structures called G-quadruplexes. Because of the rigidity and glycosidic bond orientation diversity in the stems, the flexibility of loops, and the featured alignment of several cations within one quadruplex channel, G-quadruplexes can serve as a sensitive benchmark to assess and validate current force fields for nucleic acids in molecular dynamics (MD) simulations. |
| Type |
Text |
| Publisher |
University of Utah |
| Subject |
AMBER; DNA; Glycosidic conformation; G-quadruplex; Molecular dynamics; Structural polymorphism |
| Subject LCSH |
Quadruplex nucleic acids; Molecular dynamics |
| Dissertation Institution |
University of Utah |
| Dissertation Name |
PhD |
| Language |
eng |
| Rights Management |
© Xiaohui Cang |
| Format Medium |
application/pdf |
| Source |
Original in Marriott Library Special collections, QP6.5 2010 .C255 |
| ARK |
ark:/87278/s6697j7w |
| Setname |
ir_etd |
| ID |
194086 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6697j7w |
