Resistance induced against parenteral and aerosol klebsiella pneumoniae infection in mice by specific and nonspecific immunization.

Update Item Information
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Hackett, Roberta Jensen
Title Resistance induced against parenteral and aerosol klebsiella pneumoniae infection in mice by specific and nonspecific immunization.
Date 1968-08
Description Quantitative data were gathered concerning the extent of resistance induced in mice immunized by specific and nonspecific means and subsequently challenged both parenterally and by aerosol. Animals were immunized specifically by subcutaneous injection of formalin-killed Klebsiella pneumoniae Type I which was also employed as challenge organism. The intraperitoneal LD50 was 30 bacilli. Nonspecific resistance was induced by injection of a Boivin (Difco) perpetration of Salmonella tvphimurium endotoxin. Nonspecific resistance was highest 24 hours after injection of 10 ug of endotoxin. At this time, over half the mice survived challenge with 10(2) but not 10(3) LD50. Specifically immunized mice were resistant to as much as 10(5) LD50 depending upon route of immunization. Potency ratios for parenteral challenge were: nonspecific to normal, 100, specific to normal, 10(4) to 10(5), specific to nonspecific, 10(2) to 10(3). Specific immunization protected against aerosol challenge in the LD100 range. Nonspecifically immunized animals showed significant prolongation of survival time but the 30 day mortality was similar to the control group. When aerosol challenge was in the LD50 range, the 30 day mortality showed differences between non-specifically immunized animals and control groups. The differences were not significant using groups of 30 mice.
Type Text
Publisher University of Utah
Subject Immunology; Vaccine
Subject MESH Klebsiella pneumoniae; Endotoxins
Dissertation Institution University of Utah
Dissertation Name MA
Language eng
Relation is Version of Digital reproduction of "Resistance induced against parenteral and aerosol klebsiella pneumoniae infection in mice by specific and nonspecific immunization."Spencer S. Eccles Health Sciences Library. Print version of "Resistance induced against parenteral and aerosol klebsiella pneumoniae infection in mice by specific and nonspecific immunization." available at J. Willard Marriott Library Special Collection. QR6.5 1968 .H33.
Rights Management © Roberta J. Hackett.
Format Medium application/pdf
Identifier us-etd2,24838
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6611f0g
Setname ir_etd
ID 194148
Reference URL https://collections.lib.utah.edu/ark:/87278/s6611f0g