| Publication Type |
dissertation |
| School or College |
College of Science |
| Department |
Chemistry |
| Author |
Holden, Deric Avery |
| Title |
Detection and analysis of soft nanoparticles by the resistive pulse method |
| Date |
2012-08 |
| Description |
Soft nanoparticles have become increasingly important to the scientific and medical communities particularly in drug delivery systems due to their ability to deliver drugs in a time-dependent or site-specific manner. However, much is left unexplored in their permeation and translocation through porous biological membranes, such as those found in the body. This dissertation presents investigations of the resistive-pulse detection and analysis of soft nanoparticles including microgels and liposomes, using conical nanopores embedded in glass membranes. This analysis provides a first look at the permeation and translocation of soft nanoparticles through a porous membrane. Chapter 1 overviews nanoparticles and their uses in the scientific and medical communities, as well as the resistive-pulse technique and the glass nanopore membrane. Chapter 2 describes investigations on the pressure dependent deformation and translocation of 570 nm radius pNIPAm-AAc microgels through small conical nanopores in glass membranes using the resistive-pulse technique. Translocation event rates, durations, and current pulse heights are found to be a function of the relative conductivities of the microgel and the electrolyte solution. Also, a statistical analysis technique is used to determine the probability of coincident events. |
| Type |
Text |
| Publisher |
University of Utah |
| Subject |
Soft nanoparticles; Resistive pulse; Microgels; Permeation; Translocation; Porous biological membranes |
| Subject LCSH |
Nanoparticles |
| Dissertation Institution |
University of Utah |
| Dissertation Name |
Doctor of Philosophy |
| Language |
eng |
| Rights Management |
Copyright © Deric Avery Holden 2012 |
| Format Medium |
application/pdf |
| Format Extent |
5,224,298 bytes |
| Identifier |
etd3/id/1855 |
| Source |
Original in Marriott Library Special Collections, QD3.5 2012 .H65 |
| ARK |
ark:/87278/s66m3nmn |
| Setname |
ir_etd |
| ID |
195543 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s66m3nmn |
