Multisite learning in medical image analysis

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Publication Type thesis
School or College College of Engineering
Department Computing
Author Hromatka, Michelle
Title Multisite learning in medical image analysis
Date 2015-12
Description Multisite imaging studies have the potential to accelerate scientific discovery by providing increased sample sizes, broader ranges of participant demographics, and publicly available data. However, failing to address the known nuisance variability across sites, such as scanner type or imaging protocol, reduces statistical power of any analysis performed on the multisite data. In this thesis, I present three contributions to the field of medical image analysis that are designed to reduce this known variability. These contributions include a feature reduction technique for pairwise correlation functional-magnetic resonance imaging (fMRI) data used as features in a multisite support vector machine (SVM), a subject-level network estimation technique for structural magnetic resonance imaging (MRI), and a hierarchical atlas estimation approach that accounts for intersite variability, while providing a global atlas as a common coordinate system for images across all sites. All results are presented on the Autism Brain Imaging Data Exchange (ABIDE) data set which contains resting-state fMRI (rs-fMRI) and structural MRI for 1112 subjects, including both autism and control groups. These methods result in state-of-the-art classification accuracy on the ABIDE data set and increased efficiency in reducing overall MRI data variability.
Type Text
Publisher University of Utah
Subject classification; fMRI; medical imaging; MRI; multisite learning
Dissertation Institution University of Utah
Dissertation Name Master of Science
Language eng
Rights Management © Michelle Hromatka
Format Medium application/pdf
Format Extent 27,224 bytes
Identifier etd3/id/3993
ARK ark:/87278/s65j0qmb
Setname ir_etd
ID 197543
Reference URL https://collections.lib.utah.edu/ark:/87278/s65j0qmb