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μ2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans
Synaptic vesicles must be recycled to sustain neurotransmission, in large part via clathrin-mediated endocytosis. Clathrin is recruited to endocytic sites on the plasma membrane by the AP2 adaptor complex. The medium subunit (u 2) of AP2 binds to cargo proteins and phosphatidylinositol-4,5-bisphosphate on the cell surface.
Gu, M., Schuske, K., Watanabe, S., Liu, Q., Baum, P., Garriga, G., & Jorgensen, E. M. (2008). μ2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. Journal of Cell Biology, 183(5), 881-92.