|
Publication Type |
Journal Article |
|
School or College |
College of Science |
|
Department |
Biology |
|
citation_author |
Olivera, Baldomero M.; Zhang, MinMin; Azam, Layla; Yoshikami, Doju; Bulaj, Grzegorz |
|
citation_other_author |
Green, Brad R.; Catlin, Philip; Fiedler, Brian; Chadwick, Ashley; Terlau, Heinrich; McArthur, Jeff R.; French, Robert J.; Gulyas, Josef; Rivier, Jean E.; Smith, Brian J.; Norton, Raymond S. |
|
citation_title |
Structure/function characterization of μ-Conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels |
|
citation_date |
2007 |
|
Description |
Peptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic conotoxins have already reached human clinical trials, a continuing need exists for the discovery and development of novel nonopioid analgesics, such as subtype-selective sodium channel blockers. |
|
Type |
text; |
|
citation_publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
|
citation_volume |
282 |
|
citation_issue |
42 |
|
citation_firstpage |
30699 |
|
Citation_lastpage |
30706 |
|
citation_keywords |
Conotoxins; 956;-Conotoxin KIIIA; Neuronal blocker; Neurotoxins; Sodium channel blockers; |
|
Subject (LCSH) |
Conus; Marine toxins; Sodium channels; Sodium -- Antagonists; |
|
citation_language |
eng; |
|
Bibliographic Citation |
Zhang, M.-M., Green, B. R., Catlin, P., Fiedler, B., Azam, L., Chadwick, A., Terlau, H., McArthur, J. R., French, R. J., Gulyas, J., Rivier, J. E., Smith, B. J., Norton, R. S., Olivera, B. M., Yoshikami, D., & Bulaj, G. (2007). Structure/function characterization of μ-Conotoxin KIIIA, an analgesis, nearly irreversible blocker of mammalian neuronal sodium channels. Journal of Biological Chemistry, 282(42), 30699-706. |
|
Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
|
Format-Medium |
application/pdf (portable document) |
|
Format-Extent |
432,648 bytes |
|
Identifier |
ir-main,8490 |
