| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; McIntosh, J. Michael; Yoshikami, Doju |
| Other Author |
Dowell, Cheryl; Watkins, Maren; Garrett, James E. |
| Title |
α-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors |
| Date |
2002 |
| Description |
Many venomous organisms produce toxins that disrupt neuromuscular communication to paralyze their prey. One common class of such toxins comprises nicotinic acetylcholine receptor antagonists (nAChRs). Thus, most toxins that act on nAChRs are targeted to the neuromuscular subtype. The toxin characterized in this report, α-conotoxin GIC, is a most striking exception. The 16-amino acid peptide was identified from a genomic DNA clone from Conus geographus. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Journal Title |
Journal of Biological Chemistry |
| Volume |
277 |
| First Page |
33610 |
| Last Page |
33615 |
| Subject |
Conotoxins; Conotoxin GIC; Conus geographus; Peptide antagonists |
| Subject LCSH |
Conus; Marine toxins; Nicotinic receptors; Nicotinic receptors -- Antagonists |
| Language |
eng |
| Bibliographic Citation |
McIntosh, J. M., Dowell, C., Watkins, M., Garrett, J. E., Yoshikami, D., & Olivera, B. M. (2002). α-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. Journal of Biological Chemistry, 277, 33610-5. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
278,763 bytes |
| Identifier |
ir-main,8417 |
| ARK |
ark:/87278/s68d0dnm |
| Setname |
ir_uspace |
| ID |
704952 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68d0dnm |
