Williams, Stacey L.; Lutz, Suanne; Charlie, Nicole K.; Vettel, Christiane; Ailion, Michael; Coco, Cassabdra; Tesmer, John J. G.; Wieland, Thomas; Miller, Kenneth G.
citation_title
Trio's Rho-specific GEF domain is the missing Gaq effector in C. elegans
citation_date
2007-11-01
Description
The Gaq pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhcibditis elegans, where it exerts its effects through EGL-8 (phospholipase CB [PLCB]) and at least one other effector. To find the missing effector, we performed forward genetic screens to suppress the slow growth and hyperactive behaviors of mutants with an overactive Gaq pathway.
Type
text;
citation_publisher
Cold Spring Harbor Lab Press
citation_journal_title
Genes & Development
citation_volume
21
citation_issue
21
citation_firstpage
2731
Citation_lastpage
2746
citation_doi
10.1101/gad.1592007
citatation_issn
0890-9369
citation_language
eng;
Bibliographic Citation
Williams, S. L.; Lutz, S.; Charlie, N. K.; Vettel, C.; Ailion, M.; Coco, C.; Tesmer, J. J. G.; Jorgensen, E.; Wieland, T.; Miller, K. G. (2007). Trio's Rho-specific GEF domain is the missing Gaq effector in C. elegans. Genes and Development, 21 (21), 2731-46.
Rights Management
(c) Cold Spring Harbor Laboratory Press-CSHL Press
