α-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sites
A novel conotoxin, α-conotoxin ImII (α-CTx ImII), identified from Conus imperialis venom ducts, was chemically synthesized. A previously characterized C. imperialis conotoxin, α-conotoxin ImI (α-CTx ImI), is closely related; 9 of 12 amino acids are identical. Both α-CTx ImII and α-CTx ImI functionally inhibit heterologously expressed rat α7 nAChRs with similar IC50 values.
American Society for Biochemistry and Molecular Biology (ASBMB)