Kim, Marshall; Baro, Deborah J.; Lanning, Cathy C.; Doshi, Mehul; Farnham, Jeremy; Moskowitz, Howard S.; Peck, Jack H.; Harris-Warrick, Ronald M.
citation_title
Alternative splicing in the pore-forming region of shaker potassium channels
citation_date
1997
Description
We have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming region of the protein. Three different splice variants were found within the P region, two of which bestow unique electrophysiological characteristics to channel function. Pore I and pore II variants differ in voltage dependence for activation, kinetics of inactivation, current rectification, and drug resistance.
Type
text;
citation_publisher
Society for Neuroscience
citation_firstpage
8213
Citation_lastpage
8224
citation_keywords
Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing
Subject (LCSH)
Potassium channels; Ion channels; Neurotoxic agents; Drosophila -- Genetics
citation_language
eng;
Bibliographic Citation
Kim, M., Baro, D. J., Lanning, C. C., Doshi, M., Farnham, J., Moskowitz, H. S., Peck, J .H., Olivera, B. M., & Harris-Warrick, R. M. (1997). Alternative splicing in the pore-forming region of shaker potassium channels. Journal of Neuroscience, 17, 8213-24.
