Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert
Cruz, Lourdes J.
γ-Carboxyglutamate in a neuroactive toxin
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of γ-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH3.
American Society for Biochemistry and Molecular Biology (ASBMB)