Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert
citation_other_author
Cruz, Lourdes J.
citation_title
γ-Carboxyglutamate in a neuroactive toxin
citation_date
1984
Description
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of γ-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH3.
Type
text;
citation_publisher
American Society for Biochemistry and Molecular Biology (ASBMB)
McIntosh, J. M., Olivera, B. M., Cruz, L. J., & Gray, W. R. (1984). γ-Carboxyglutamate in a neuroactive toxin. Journal of Biological Chemistry, 259, 14343-6.
Rights Management
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/
