Nonet, Michael L.; Staunton, Jane E.; Kilgard, Michael P.; Fergestad, Tim; Hartwieg, Erika; Horvitz, H. Robert; Meyer, Barbara J.
citation_title
Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles
citation_date
1997
Description
Rab molecules regulate vesicular trafficking in many different exocytic and endocytic transport pathways in eukaryotic cells. In neurons, rab3 has been proposed to play a crucial role in regulating synaptic vesicle release. To elucidate the role of rab3 in synaptic transmission, we isolated and characterized Caenorhabditis elegans rab-3 mutants. Similar to the mouse rab3A mutants, these mutants survived and exhibited only mild behavioral abnormalities. In contrast to the mouse mutants, synaptic transmission was perturbed in these animals.
Type
text;
citation_publisher
Society for Neuroscience
citation_volume
17
citation_issue
21
citation_firstpage
8061
Citation_lastpage
8073
citation_language
eng;
Bibliographic Citation
Nonet, M. L., Staunton, J. E., Kilgard, M., Fergestad, T., Hartwieg, E., Horvitz, H. R., Jorgensen, E., & Meyer, B. J. (1997). Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Journal of Neuroscience, 17(21), 8061-73.
