Nam, Kweon-Ho; Kennedy, Anne M.; Rapoport, Natalya
Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions
Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydrophobic block. Acoustic droplet vaporization (ADV) and cavitation parameters were measured as a function of ultrasound frequency, pressure, duty cycles, and temperature. The optimal parameters that induced ADV and inertial cavitation of the formed microbubbles were used in vivo in the experiments on the ultrasound-mediated chemotherapy of ovarian cancer. A combination tumor treatment by intravenous injections of drug-loaded perfluoropentane nanoemulsions and tumor-directed 1-MHz ultrasound resulted in a dramatic decrease of ovarian or breast carcinoma tumor volume and sometimes complete tumor resolution. However, tumors often recurred three to six weeks after the treatment indicating that some cancer cells survived the treatment. The recurrent tumors proved more aggressive and resistant to the repeated therapy than initial tumors suggesting selection for the resistant cells during the first treatment.
American Institute of Physics (AIP)
Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane;
Cancer -- Treatment; Drug delivery systems; Emulsions (Pharmacy);
8TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND; 10; Minneapolis (Minnesota)
Nam, K.-H., Christensen, D. A., Kennedy, A. M., & Rapoport, N. (2009). Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions. AIP Conference Proceedings, 1113, 124-8.
(c)American Institute of Physics. The following article appeared in by Nam, K.-H., Christensen, D. A., Kennedy, A. M., & Rapoport, N. AIP Conference Proceedings. 1113 2009 and may be found at DOI:10.1063/1.3131396.